CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 121 enrolled
Drug / intervention
ivabradine +2 moredrug
Likely dose
ivabradine 7.5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01178528
NCT01178528Phase 3Completed
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Effect of Ivabradine, Carvedilol or Their Combination in Patients With Heart Failure

IRCCS San Raffaele·interventional·Posted Aug 10, 2010·Updated Sep 30, 2014

In Brief

A Phase 3 clinical trial evaluating ivabradine, "Drug:Carvedilol" and "Drug:Ivabradine", and 1 other intervention for Heart Failure. Completed, enrolled 121 participants across 2 sites.

Detailed Summary

Patients with heart failure (HF) have a limited exercise tolerance,few pharmacological interventions have been proven effective in improving exercise capacity. At the presence there i conflicting evidence on the effectiveness of beta-blockers on exercise capacity. Ivabradine has been shown to improve prognosis in patients with ischemic heart disease, left ventricular dysfunction and heart rate \> 70 bpm. The association of ivabradine and atenolol has been proven effective in increasing exercise tolerance in patients with ischemic heart disease. Aim of the present study is to evaluate the effect of heart rate reduction with ivabradine, carvedilol or their combination in patients with heart failure of ischemic origin.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHeart Failure
CountriesItaly
Collaborators--

Timeline

Phase 3CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedAug 10, 2010
Enrollment StartSep 1, 2009
Primary CompletionJun 1, 2010
Study CompletionOct 1, 2010
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 15.9 years ago

Interventions

ivabradinedrug

7.5 mg bd

"Drug:Carvedilol" and "Drug:Ivabradine"drug

up to 12.5/5 mg bd

Carvediloldrug

25 mg bd