CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 122 enrolled
Drug / intervention
ACH-0141625 (Sovaprevir) +5 moredrug
Likely dose
ACH-0141625 (Sovaprevir) 200 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01180790
NCT01180790Phase 2Completed

A Phase IIa, Randomized, Double-blind (Participant and Investigator Blind, Sponsor Open), Placebo-controlled Trial to Evaluate the Safety, Tolerability, and Antiviral Activity of Oral ACH-0141625 in Combination With Pegylated Interferon Alpha-2a and Ribavirin in Two Segments, After 28 Days of Dosing and, Subsequently, After 12 Weeks of Dosing in Participants With Chronic Hepatitis C Virus Genotype 1

Alexion Pharmaceuticals, Inc.·interventional·Posted Aug 12, 2010·Updated Aug 30, 2023

In Brief

A Phase 2 clinical trial evaluating ACH-0141625 (Sovaprevir), Placebo, and 2 other interventions for Hepatitis C. Completed, enrolled 122 participants across 18 sites in 2 countries.

Detailed Summary

Evaluate safety, tolerability, and antiviral response of ACH-0141625 compared to standard of care in hepatitis C virus (HCV)-positive participants.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHepatitis C
CountriesBelgium, United States

Timeline

Phase 2CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedAug 12, 2010
Enrollment StartSep 1, 2010
Primary CompletionMar 1, 2012
Study CompletionApr 1, 2013
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 15.9 years ago

Interventions

ACH-0141625 (Sovaprevir)drug

200 mg oral capsule once daily

ACH-0141625 (Sovaprevir)drug

400 mg oral capsule once daily

ACH-0141625 (Sovaprevir)drug

800 mg oral capsule once daily

Placebodrug

Powder in capsule once daily

Pegylated Interferon alpha-2adrug

180 micrograms (ug) once a week by subcutaneous injection

Ribavirindrug

400 mg or 600 mg (morning \[AM\]) and 600 mg (evening \[PM\]) capsules taken orally twice daily