At a glance
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Exenatide and Postprandial Endothelial Dysfunction: Effects and Mechanisms
In Brief
A Phase 4 clinical trial evaluating Exenatide SC, Exenatide IV, and 3 other interventions for Type 2 Diabetes Mellitus. Completed, enrolled 76 participants across 1 site.
Detailed Summary
The purpose of this investigation is to evaluate whether exenatide, a type 2 diabetes medication, will improve the function of the innermost part of the arterial wall called the endothelium after a fat-enriched meal and to determine how this occurs. The results of this study will help to determine and understand a novel action of this group of diabetes medications based on the action of naturally occuring gut substances called incretins. This may have a significant impact on cardiovascular health in patients with early and longstanding diabetes.
Study Details
Timeline
Interventions
Exenatide 5-10 ug sc BID/10 days
50 ng/min intravenously for 45 minutes on 2 out of 3 study visits separated by 5-10 days
Placebo sc BID/10days
Primed (6,000 pM/kg), continuous (600 pM/kg) intravenous infusion for 75 minutes on 1 out of 3 study visits.
Intravenous infusion for 45 minutes on 1 out of 3 visits