CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 987 enrolled
Drug / intervention
Intervention is blood pressure management approach +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

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NCT01192412N/ACompleted
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The CHIPS Trial (Control of Hypertension In Pregnancy Study)

University of British Columbia·interventional·Posted Sep 1, 2010·Updated Jan 11, 2017

In Brief

A clinical study evaluating Intervention is blood pressure management approach and Intervention is blood pressure management approach. for Gestational Hypertension. Completed, enrolled 987 participants across 111 sites in 15 countries.

Detailed Summary

The investigators do not know which approach to treatment of non-severe high blood pressure in pregnancy is better for women and babies. In the CHIPS Trial, the investigators seek to determine whether 'less tight' control (aiming for a diastolic blood pressure \[dBP\] of 100 mmHg), compared with 'tight' control (aiming for a diastolic blood pressure \[dBP\] of 85 mmHg) can decrease the risks of adverse baby outcomes without increasing the risk of problems for the mother.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGestational Hypertension
CountriesArgentina, Australia, Brazil, Canada, Chile, Colombia, Estonia, Hungary, Israel, Jordan, Netherlands, New Zealand, Poland, United Kingdom, United States
CollaboratorsCanadian Institutes of Health Research (CIHR), Sunnybrook Research Institute

Timeline

N/ACompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedSep 1, 2010
Enrollment StartApr 1, 2009
Primary CompletionFeb 1, 2014
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 15.8 years ago

Interventions

Intervention is blood pressure management approachprocedure

1\) 'Less tight' control. The dBP treatment goal is 100 mmHg. For safety, if dBP is \>105 mmHg, then antihypertensive medication must be started or increased in dose. For dBP \<100 mmHg, antihypertensive therapy should be decreased in dose or stopped, as appropriate. The intervention will be applied until delivery.

Intervention is blood pressure management approach.procedure

'Tight' control. The dBP treatment goal is 85 mmHg. For safety, if dBP is \<80 mmHg, then antihypertensive medication must be decreased in dose or discontinued. If dBP is \>85 mmHg, then antihypertensive therapy should be started or increased in dose. The intervention will be applied until delivery.