CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 11 enrolled
Drug / intervention
Prednisone +1 moredrug
Likely dose
Prednisone 25 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01193049
NCT01193049Phase 1Completed
CompareCT.gov

A Two-Part, Randomized Clinical Trial to Study the Effects of a Single Dose of Prednisone on Biomarkers of Allergen Responses in Asthmatics

Merck Sharp & Dohme LLC·interventional·Posted Sep 1, 2010·Updated Sep 4, 2015

In Brief

A Phase 1 clinical trial evaluating Prednisone and Placebo for Asthma. Completed, enrolled 11 participants.

Detailed Summary

The purpose of this study is to evaluate the relationship between upper and lower airway allergen-induced cytokine responses in mild asthmatics by attempting to demonstrate the following: 1) a positive correlation between allergen-induced Type 2 T-helper cell (Th2) cytokines (interleukins 5 and 13) in sputum and nasal exudates; and 2) a positive correlation between effects of prednisone versus placebo on Th2 cytokines in sputum and nasal exudates.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAsthma
Countries--
Collaborators--

Timeline

Phase 1CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedSep 1, 2010
Enrollment StartAug 1, 2010
Primary CompletionMay 1, 2011
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 15.8 years ago

Interventions

Prednisonedrug

Prednisone (25 mg) tablets as a single oral dose on Day 1 of each study period

Placebodrug

Matching placebo tablets as a single oral dose on Day 1 of each study period