CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 2,140 enrolled
Drug / intervention
MRSA Decolonization +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01209234
NCT01209234N/ACompleted
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Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance

University of California, Irvine·interventional·Posted Sep 27, 2010·Updated Nov 21, 2025

In Brief

A clinical study evaluating Standard-of-Care Education and MRSA Decolonization for Methicillin-resistant Staphylococcus Aureus. Completed, enrolled 2,140 participants across 24 sites.

Detailed Summary

This randomized controlled trial will compare strategies to reduce the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection and re-hospitalization in MRSA carriers. This trial will provide critical answers about the role of decolonization versus standard-of-care education in preventing MRSA infections in the large group of high risk MRSA-positive patients being discharged from hospitals. Findings could potentially impact best practice for the 1.8 million MRSA carriers who are discharged from US hospitals each year.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMethicillin-resistant Staphylococcus Aureus
CountriesUnited States
CollaboratorsAgency for Healthcare Research and Quality (AHRQ)

Timeline

N/ACompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedSep 27, 2010
Enrollment StartJan 1, 2011
Primary CompletionJan 1, 2019
TodayJul 2, 2026
Enrollment to primary: 8 yearsPosted 15.8 years ago

Interventions

Standard-of-Care Educationbehavioral

Patients randomized to standard education will receive a binder with MRSA educational materials which will include or be based upon CDC guidance for MRSA patients at home.

MRSA Decolonizationdrug

Participants in this arm will be instructed to complete a decolonization regimen that will involve a 5-day application of nasal mupirocin, oral CHG rinse, and CHG body wash twice a month.