CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 32 enrolled
Drug / intervention
Fluticasone +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01216735
NCT01216735N/ACompleted
CompareCT.gov

Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers

University of Miami·interventional·Posted Oct 7, 2010·Updated Jun 29, 2016

In Brief

A clinical study evaluating Fluticasone and Placebo for Tobacco Abuse Smoke. Completed, enrolled 32 participants across 1 site.

Detailed Summary

The hypothesis underlying the proposed study is that the blunted endothelium-dependent vasodilation seen in the airway of current smokers is also present in the brachial artery, and that the same inhaled corticosteroid (ICS) treatment regime that reversed endothelial function in the airway of current smokers will also restore endothelium-dependent relaxation in the brachial artery. Non-smokers will be used as controls and will not receive any intervention or treatment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTobacco Abuse Smoke
CountriesUnited States
CollaboratorsGlaxoSmithKline

Timeline

N/ACompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedOct 7, 2010
Enrollment StartSep 1, 2008
Primary CompletionDec 1, 2009
Study CompletionSep 1, 2010
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 15.7 years ago

Interventions

Fluticasonedrug

220 ug twice a day for 3 weeks

Placebodrug

Placebo for 3 weeks