At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans
In Brief
A Phase 2 clinical trial evaluating Propranolol, Placebo to Match Propranolol, and 1 other intervention for Hyperalgesia. Completed, enrolled 10 participants across 1 site.
Detailed Summary
This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil). Beta blockers inhibit the sympathetic (fight or flight) response and are often used to treat angina and high blood pressure. In a previous study in human volunteers, the investigators demonstrated an increased sensitivity to pain after a 60-minute infusion of the opioid remifentanil. The goal of this study is to identify a possible inhibitor of this phenomenon.
Study Details
Timeline
Interventions
Propranolol administered intravenously, initially set to target plasma concentration of 5 ng/mL, titrated upward in 5 ng/mL intervals until a final concentration of 15 ng/mL is achieved.
Remifentanil administered intravenously at a plasma concentration of 3 ng/mL.