CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 150 enrolled
Drug / intervention
Hot Compress plus Tobramycin Drops and Ointment +2 moredrug
Likely dose
Not stated in record
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Search/NCT01230593
NCT01230593N/ACompleted

A 5-year Multicenter Prospective Randomized Trial Comparing Three Conservative Chalazion Treatments

McMaster University·interventional·Posted Oct 29, 2010·Updated Jun 12, 2018

In Brief

A clinical study evaluating Hot Compress plus Tobramycin Drops and Ointment, Hot compress plus Tobramycin/Dexamethasone Drops and Ointment, and 1 other intervention for Chalazion Unspecified Eye, Unspecified Eyelid and 3 related conditions. Completed, enrolled 150 participants across 3 sites in 2 countries.

Detailed Summary

An eyelid stye, or chalazion, is the most common eyelid ailment, and is caused by the blockage of one of the oil secreting glands of the eyelid (meibomian glands). This leads to a typically painful, swollen, and red eyelid bump that lasts from days to weeks and months. The chalazion may cause tearing, pressure on the cornea, and irritation, all of which contribute to its morbidity. There are many anecdotal first line treatments for this condition, including warm compresses to the eyelid, topical antibiotics, topical steroids, topical combination antibiotic/steroid, and oral antibiotics. There have been no clinical trials to compare the efficacy of any of these conservative treatments. We wish to determine the most effective conservative medical treatment for chalazia.

Study Details

Timeline

N/ACompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedOct 29, 2010
Enrollment StartNov 1, 2010
Primary CompletionJan 1, 2016
Study CompletionMar 1, 2016
TodayJul 2, 2026
Enrollment to primary: 5.2 yearsPosted 15.7 years ago

Interventions

Hot Compress plus Tobramycin Drops and Ointmentdrug

In addition to hot compress, Tobramycin drops will be given to the affected eye 3x/day, and Tobramycin ointment will be given at night before bed.

Hot compress plus Tobramycin/Dexamethasone Drops and Ointmentdrug

In addition to hot compress, Tobramycin/Dexamethasone drops will be given to the affected eye 3x/day, and Tobramycin/Dexamethasone ointment will be given at night before bed.

Hot Compressesother

Hot compresses 3x/day to eyelids