CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 200 enrolled
Drug / intervention
Evicel fibrin sealantdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01235715
NCT01235715Phase 4Completed

The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery

Hospital for Special Surgery, New York·interventional·Posted Nov 5, 2010·Updated Oct 29, 2013

In Brief

A Phase 4 clinical trial evaluating Evicel fibrin sealant for Osteoarthritis. Completed, enrolled 200 participants across 1 site.

Detailed Summary

Application of "Evicel" hemostatic matrix during operation for unilateral total knee replacement surgery (TKA) will result in decreased bleeding and postoperative drain output, a reduction in transfusion requirements, and less reduction of hemoglobin.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOsteoarthritis
CountriesUnited States
CollaboratorsEthicon, Inc.

Timeline

Phase 4CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedNov 5, 2010
Enrollment StartSep 1, 2010
Primary CompletionMar 1, 2012
Study CompletionSep 1, 2012
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 15.7 years ago

Interventions

Evicel fibrin sealantdrug

Used for hemostasis to control bleeding. It has been shown to stop bleeding in 2 minutes or less. It is a combination of a biologic activated component containing human fibrinogen and topical thrombin functioning on wet, actively bleeding tissue.