CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 24 enrolled
Drug / intervention
Placebo low dose +5 moredrug
Likely dose
N Acetyl cysteine, 600mg (low dose)from record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01251315
NCT01251315Phase 1Completed

PILOT: The Effects of Short Term Administration of a Novel Glutathione Precursor (FT061452), on Serum and Intracellular Glutathione Levels

Charles Drew University of Medicine and Science·interventional·Posted Dec 1, 2010·Updated Apr 14, 2014

In Brief

A Phase 1 clinical trial evaluating Placebo low dose, N Acetyl cysteine, 600mg (low dose), and 4 other interventions for Oxidative Stress. Completed, enrolled 24 participants across 1 site.

Detailed Summary

Glutathione is a powerful protective substance found within every cell in the body. It has been shown that glutathione levels go down as a person gets older, which makes a person more likely to get heart disease, high blood sugar problems and different kind of cancers. N-Acetyl Cysteine is used as a dietary supplement. It has been reported to increase glutathione levels in the body. The diet supplement called ProImmune is also changed by the body into glutathione. Therefore, the purpose of this study is to find out the effect of ProImmune in healthy people. This study will also help to prove whether or not the ProImmune is able to improve the blood levels of glutathione in healthy people.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedDec 1, 2010
Enrollment StartDec 1, 2010
Primary CompletionJun 1, 2011
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 15.6 years ago

Interventions

Placebo low dosedrug

This is a prospective randomized controlled pilot study, which will include twenty-four (24) healthy individuals.The first 12 subjects (low dose) will be randomized into three sub groups. The first group will be given a single dose of placebo.

N Acetyl cysteine, 600mg (low dose)drug

The sub-group of four subjects (low dose) will be given a single dose of 600 mg of N-Acetyl Cysteine (NAC).

Proimmune 200 (FT061452) 3000mg low dosedrug

The sub-group of four subjects (low dose) will be given a single dose of Proimmune 200 (FT061452) 3000mg low dose'

Placebo (high dose)drug

The second sub set of 12 subjects (high dose) will be randomized into three sub groups. The first group will be given a single dose of placebo.

N Acetyl cysteine, 1200mg (high dose)drug

N Acetyl cysteine (high dose) N-Acetyl Cysteine(NAC)1200mg (high dose) given as a single dose.

FT061452, 6000mg high dosedrug

Proimmune 200(FT061452) high dose group given 6000 mg as a single dose.