At a glance
ClinicalIndex Comparison RecordPhase 3Completed· 111 enrolled
Drug / intervention
Biperiden +1 moredrug
Likely dose
Biperiden 6mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Cocaine/Crack Dependence: A Study of the Possible Reduction of Compulsion Under the Use of Biperiden
In Brief
A Phase 3 clinical trial evaluating Biperiden and Placebo for Cocaine Dependence. Completed, enrolled 111 participants across 1 site.
Detailed Summary
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process. Then the present study aims to evaluate biperiden efficacy (a cholinergic antagonist) in attenuate compulsion, one o the main symptoms of the drug dependence.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCocaine Dependence
CountriesBrazil
Timeline
Phase 3CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedDec 2010
Enrollment StartMay 2011
Primary CompletionDec 2011
Study CompletionNov 2012
TodayJul 2026
First PostedDec 1, 2010
Enrollment StartMay 1, 2011
Primary CompletionDec 1, 2011
Study CompletionNov 1, 2012
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 15.6 years ago
Interventions
Biperidendrug
Thirty volunteers will take three pills of Biperiden (6mg/day) during two months.
Placebodrug
Thirty volunteers will take three pills of Placebo (6mg/day) during two months.