CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 98 enrolled
Drug / intervention
SFN-rich broccoli sprout extract capsules +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01265953
NCT01265953N/ACompleted
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Chemoprevention of Prostate Cancer, HDAC Inhibition and DNA Methylation

Portland VA Medical Center·interventional·Posted Dec 23, 2010·Updated May 1, 2019

In Brief

A clinical study evaluating SFN-rich broccoli sprout extract capsules and Gelatin capsule containing microcrystalline cellulose. for Prostate Cancer Prevention. Completed, enrolled 98 participants across 2 sites.

Detailed Summary

The objective of the study is to identify mechanisms by which compounds found in cruciferous vegetables alter gene expression via epigenetic modifications (changes in gene expression) and may prevent prostate cancer development. The investigators have found that sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, inhibits histone deacetylase (HDAC) activity in human colorectal and prostate cancer cells.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsProstate Cancer Prevention
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI), Oregon State University, OHSU Knight Cancer Institute

Timeline

N/ACompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedDec 23, 2010
Enrollment StartJul 1, 2011
Primary CompletionOct 1, 2015
Study CompletionDec 1, 2015
TodayJul 2, 2026
Enrollment to primary: 4.3 yearsPosted 15.5 years ago

Interventions

SFN-rich broccoli sprout extract capsulesdrug

Four weeks SFN-rich broccoli sprout extract (BSE) capsules: 200µmol of SFN, 2 capsules (1 capsule B.I.D.) daily

Gelatin capsule containing microcrystalline cellulose.dietary

Four weeks placebo capsules: 2 capsules (1 capsule B.I.D.) daily