At a glance
ClinicalIndex Comparison RecordPhase 2Completed· 38 enrolled
Drug / intervention
Estradiol oral capsule +3 moredrug
Likely dose
Estradiol oral capsule 1 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of Low Dose Estrogen on Cortical Function as a Function of Age in Postmenopausal Women.
In Brief
A Phase 2 clinical trial evaluating Estradiol oral capsule, transderman estrogen patch, and 2 other interventions for Memory Loss and 2 related conditions. Completed, enrolled 38 participants across 1 site.
Detailed Summary
This study will focus on how estrogen affects parts of the brain associated with memory and how the effect of estrogen is altered with aging in postmenopausal women.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMemory Loss, Cognitive Changes, Postmenopausal Symptoms
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA)
Timeline
Phase 2CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
Enrollment StartNov 2009
First PostedDec 2010
Primary CompletionDec 2013
TodayJul 2026
First PostedDec 29, 2010
Enrollment StartNov 1, 2009
Primary CompletionDec 2, 2013
TodayJul 2, 2026
Enrollment to primary: 4.1 yearsPosted 15.5 years ago
Interventions
Estradiol oral capsuledrug
1 oral capsule (1 mg estradiol) administered daily for one month
transderman estrogen patchdrug
transdermal estrogen patch (50 mcg/day) for one month
trasdermal placebo patchdrug
transdermal placebo patch with patch change every 84 hr for one month
placebo oral capsuledrug
placebo oral capsule administered daily for one month.