CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 108 enrolled
Drug / intervention
A. Control Nerve Block. IV Dexamethasone (4 mg). +4 moredrug
Likely dose
A. Control Nerve Block. IV Dexamethasone (4 mg).from record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01277159
NCT01277159N/ACompleted
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Duration of Analgesia After Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine

Hospital for Special Surgery, New York·interventional·Posted Jan 14, 2011·Updated Apr 14, 2022

In Brief

A clinical study evaluating A. Control Nerve Block. IV Dexamethasone (4 mg)., B. Nerve Block with Dexamethasone (4 mg). IV saline., and 3 other interventions for Patients Undergoing Ankle Surgery. Completed, enrolled 108 participants across 1 site.

Detailed Summary

Patients scheduled to go home after ankle surgery at HSS typically receive a sciatic nerve block in the popliteal fossa and oral analgesic tablets (such as Percocet). Popliteal fossa nerve blockade has reduced pain for these patients (YaDeau et al, Anesth Analg 2008;106:1916-20), but unfortunately the patients still often experience moderate to severe pain after the block wears off. The investigators wish to study two additives that may prolong the period of analgesia provided by the nerve block. The additives will be studied in the context of a standardized postoperative multimodal analgesic pathway. Primary outcome: Does adding dexamethasone and / or buprenorphine prolong the analgesia provided by a popliteal fossa nerve block?

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPatients Undergoing Ankle Surgery
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedJan 14, 2011
Enrollment StartOct 1, 2010
Primary CompletionDec 1, 2011
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 15.5 years ago

Interventions

A. Control Nerve Block. IV Dexamethasone (4 mg).drug

A. Control Nerve Block. IV Dexamethasone (4 mg).

B. Nerve Block with Dexamethasone (4 mg). IV saline.drug

B. Nerve Block with Dexamethasone (4 mg). IV saline.

C. Control Nerve Block. IV Dexamethasone (4 mg). IV Buprenorphine (0.3 mg)drug

C. Control Nerve Block. IV Dexamethasone (4 mg). IV Buprenorphine (0.3 mg)

D. Nerve Block with Buprenorphine (0.3 mg). IV Dexamethasone (4 mg).drug

D. Nerve Block with Buprenorphine (0.3 mg). IV Dexamethasone (4 mg).

E. Nerve Block with Dexamethasone (4 mg) / block Buprenorphine (0.3 mg).drug

E. Nerve Block with Dexamethasone (4 mg) / block Buprenorphine (0.3 mg). IV saline.