CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 120 enrolled
Drug / intervention
rituximabdrug
Likely dose
rituximab 125mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01280682
NCT01280682Phase 4Completed

Immune Intervention With Anti-CD20 Monoclonal Antibody to Preserve Beta Cell Function in Early Onset Type 1 Diabetes

Yang Tao·interventional·Posted Jan 21, 2011·Updated Dec 11, 2023

In Brief

A Phase 4 clinical trial evaluating rituximab for Type 1 Diabetes. Completed, enrolled 120 participants across 1 site.

Detailed Summary

Transient elimination of B lymphocytes with anti-CD20 monoclonal antibody would decrease immune-mediated destruction of beta cells and result in preserved beta-cell function in patients with type 1 diabetes of recent onset.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsType 1 Diabetes
CountriesChina
Collaborators--

Timeline

Phase 4CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedJan 21, 2011
Enrollment StartJul 1, 2010
Primary CompletionDec 1, 2016
Study CompletionDec 1, 2018
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 15.4 years ago

Interventions

rituximabdrug

anti-CD20 monoclonal antibody 125mg/m\^2 day1 day8 day15 day22 repeat after six months (only day1 and day8)