CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 100 enrolled
Drug / intervention
Proton radiotherapyradiation
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01288235
NCT01288235Phase 2Completed

A Phase II Study of Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation: An Assessment of Long Term Neurocognitive, Neuroendocrine Adn Ototoxicity Outcomes

Massachusetts General Hospital·interventional·Posted Feb 2, 2011·Updated Jun 3, 2025

In Brief

A Phase 2 clinical trial evaluating Proton radiotherapy for Brain Tumor and 4 related conditions. Completed, enrolled 100 participants across 2 sites.

Detailed Summary

Some patients with brain tumors receive standard radiation to help prevent tumor growth. Although standard radiation kills tumor cells, it can also damage normal tissue in the process and lead to more side effects. This research study is looking at a different form of radiation called proton radiotherapy which helps spare normal tissues while delivering radiation to the tumor or tumor bed. Proton techniques irradiate 2-3 times less normal tissue then standard radiation. This therapy has been used in treatment of other cancers and information from those other research studies suggests that this therapy may help better target brain tumors then standard radiation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedFeb 2, 2011
Enrollment StartFeb 1, 2011
Primary CompletionSep 1, 2016
TodayJul 2, 2026
Enrollment to primary: 5.6 yearsPosted 15.4 years ago

Interventions

Proton radiotherapyradiation

5 days a week