At a glance
ClinicalIndex Comparison RecordPhase 3Completed· 60 enrolled
Drug / intervention
Ketamine +1 moredrug
Likely dose
Ketamine 5mcg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia Using Filaments, an Algometer, and Interleukins: a Double-blind, Randomized Study
In Brief
A Phase 3 clinical trial evaluating Ketamine and Saline for Pain and 2 related conditions. Completed, enrolled 60 participants across 1 site.
Detailed Summary
The aim of this study was to determine if the addition of ketamine reduces remifentanil-induced hyperalgesia, improves its analgesic effect, inhibits IL(interleukin)-6 and IL-8 (inflammatory cytokines), and stimulates IL-10 (an anti-inflammatory cytokine).
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPain, Hyperalgesia, Inflammatory Response
CountriesBrazil
CollaboratorsFundação de Amparo à Pesquisa do Estado de São Paulo
Timeline
Phase 3CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
Enrollment StartSep 2010
First PostedFeb 2011
Primary CompletionSep 2012
TodayJul 2026
First PostedFeb 23, 2011
Enrollment StartSep 1, 2010
Primary CompletionSep 1, 2012
TodayJul 2, 2026
Enrollment to primary: 2 yearsPosted 15.4 years ago
Interventions
Ketaminedrug
Patients in group ketamine was administrated ketamine (5mcg/kg/min) during the surgery.
Salinedrug
Patients in group N (placebo) was administrated saline during surgery.