At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Immunomodulatory Properties of Fresh Versus Stored Packed Red Blood Cells for Transfusion
In Brief
A clinical study evaluating Fresh transfusion and Old transfusion for Iron, Abnormal Blood Level and Other Abnormal Blood Chemistry. Completed, enrolled 14 participants across 1 site.
Detailed Summary
Packed red blood cell units destined for transfusion can be stored for up to 42 days prior to transfusion based on Food and Drug Administration (FDA) guidelines. Recent studies suggest that certain patients transfused with blood stored for longer duration have poorer outcomes than patients transfused fresher blood. The investigators' hypothesis is that the delivery of an immediate and substantial load of hemoglobin-associated iron from a stored unit of blood leads to changes that explain the differences in outcome between patients transfused old versus fresh blood. The investigators propose to test this hypothesis in humans by transfusing an individual's own blood, both fresh and after storage, and comparing levels of various outcome measures.
Study Details
Timeline
Interventions
1 unit autologous transfusion of red blood cells stored for 3-7 days under standard conditions
1 unit autologous transfusion of red blood cells stored for 40-42 days under standard conditions