At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Modifiable Effectors of Renin System Activation: Treatment Evaluation (MODERATE)
In Brief
A Phase 3 clinical trial evaluating Vitamin D ergocalciferol, Probenecid, and 2 other interventions for Renal Function and 4 related conditions. Completed, enrolled 242 participants across 1 site.
Detailed Summary
The investigators hypothesize that, among non-hypertensive overweight and obese individuals, treatment of vitamin D deficiency and lowering uric acid concentrations (by either xanthine oxidase inhibition or increased renal excretion) will attenuate renin angiotensin system (RAS) activation, improve endothelial function, and lower blood pressure.
Study Details
Timeline
Interventions
50,000 unit soft gel capsule once per week for 8 weeks
500 mg tablet once per day for 4 weeks, then either 500 mg tablet once per day for 4 weeks or 1000 mg once per day for 4 weeks (8 weeks total)
300 mg tablet once per day for 4 weeks then either 300 mg once per day or 600 mg once per day for 4 weeks (8 weeks total)
Placebo soft gel once per week for 8 weeks
Placebo tablet once per day for 4 weeks then twice per day for 4 weeks (eight weeks total)