At a glance
ClinicalIndex Comparison RecordPhase 2Completed· 48 enrolled
Drug / intervention
IV Propranolol and Per Tube Clonidine +1 moredrug
Likely dose
IV Propranolol and Per Tube Clonidine 1 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Severe Traumatic Brain Injury, A Pilot Randomized Clinical Trial Using Propranolol and Clonidine
In Brief
A Phase 2 clinical trial evaluating IV Propranolol and Per Tube Clonidine and Placebo for Brain Injuries and 3 related conditions. Completed, enrolled 48 participants across 1 site.
Detailed Summary
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI). The primary hypothesis is that adrenergic blockade after severe TBI will be associated with increased ventilator-free days.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Timeline
Phase 2CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedMar 2011
Enrollment StartAug 2011
Primary CompletionJan 2015
Study CompletionDec 2016
TodayJul 2026
First PostedMar 24, 2011
Enrollment StartAug 1, 2011
Primary CompletionJan 1, 2015
Study CompletionDec 1, 2016
TodayJul 2, 2026
Enrollment to primary: 3.4 yearsPosted 15.3 years ago
Interventions
IV Propranolol and Per Tube Clonidinedrug
1 mg IV q6h Propranolol and 0.1 mg Per Tube Clonidine, both for 7 days
Placebodrug
Placebo IV q6h and Per Tube q12, both for 7 days