CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 3,706 enrolled
Drug / intervention
Not specified
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01322165
NCT01322165N/ACompleted
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National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

National Heart, Lung, and Blood Institute (NHLBI)·observational·Posted Mar 24, 2011·Updated Dec 20, 2016

In Brief

An observational study for Marfan Syndrome and 11 related conditions. Completed, enrolled 3,706 participants across 7 sites.

Detailed Summary

The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac/.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsMarfan Syndrome, Turner Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome, FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation, Bicuspid Aortic Valve Without Known Family History, Bicuspid Aortic Valve With Family History, Bicuspid Aortic Valve With Coarctation, Familial Thoracic Aortic Aneurysm and Dissections, Shprintzen-Goldberg Syndrome, Other Aneur/Diss of Thoracic Aorta Not Due to Trauma, <50yo, Other Congenital Heart Disease
CountriesUnited States
CollaboratorsNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Timeline

N/ACompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMar 24, 2011
Enrollment StartNov 1, 2007
Primary CompletionSep 1, 2015
Study CompletionSep 1, 2016
TodayJul 2, 2026
Enrollment to primary: 7.8 yearsPosted 15.3 years ago