CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 60 enrolled
Drug / intervention
Ischemic Preconditioningprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01333969
NCT01333969N/ACompleted
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The Effect of Ischemic Preconditioning on Postoperative Pain After Total Knee Arthroplasty, a Randomized, Controlled Trial

Hospital for Special Surgery, New York·interventional·Posted Apr 12, 2011·Updated Dec 27, 2024

In Brief

A clinical study evaluating Ischemic Preconditioning for Total Knee Arthroplasty and 2 related conditions. Completed, enrolled 60 participants across 1 site.

Detailed Summary

The application of a tourniquet for 5 minutes and subsequent reperfusion before actual inflation of the tourniquet for total knee arthroplasty (ischemic preconditioning) decreases the level of local inflammation and therefore postoperative pain in response to reperfusion of the ischemic extremity.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTotal Knee Arthroplasty, Ischemic Preconditioning, Postoperative Pain
CountriesUnited States
CollaboratorsUniversity of Massachusetts, Worcester

Timeline

N/ACompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedApr 12, 2011
Enrollment StartApr 1, 2011
Primary CompletionApr 1, 2012
TodayJul 2, 2026
Enrollment to primary: 1 yearPosted 15.2 years ago

Interventions

Ischemic Preconditioningprocedure

In the study group, the patients' operative limb will be preconditioned by inflating the tourniquet for 5 minutes, followed by deflation and a 5-minute reperfusion period. Subsequently, the tourniquet will be inflated for the entire length of the operation (before skin incision to after insertion of the final components). In the control group, the tourniquet will be used for the entire length of the operation without a preconditioning phase.