CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 34 enrolled
Drug / intervention
prednisone +12 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01336933
NCT01336933Phase 2Completed
CompareCT.gov

A Phase II Study of Cyclophosphamide, Etoposide, Vincristine and Prednisone (CEOP) Alternating With Pralatrexate (P) as Front Line Therapy for Patients With Stage II, III and IV Peripheral T-Cell Non-Hodgkin Lymphoma

University of Nebraska·interventional·Posted Apr 18, 2011·Updated Sep 22, 2023

In Brief

A Phase 2 clinical trial evaluating prednisone, cyclophosphamide, and 11 other interventions for Anaplastic Large Cell Lymphoma and 3 related conditions. Completed, enrolled 34 participants across 9 sites.

Detailed Summary

This phase II trial studies how well combination chemotherapy and pralatrexate works in treating patients with non-Hodgkin lymphoma (NHL). Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Hepatosplenic T-cell Lymphoma, Peripheral T-cell Lymphoma
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI), Spectrum Pharmaceuticals, Inc

Timeline

Phase 2CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedApr 18, 2011
Enrollment StartJul 6, 2011
Primary CompletionDec 28, 2016
TodayJul 2, 2026
Enrollment to primary: 5.5 yearsPosted 15.2 years ago

Interventions

prednisonedrug

Given PO

cyclophosphamidedrug

Given IV

etoposidedrug

Given PO or IV

Vincristinedrug

Given IV

pralatrexatedrug

Given IV

laboratory biomarker analysisother

Correlative studies

comparative genomic hybridizationgenetic

Correlative studies

gene expression analysisgenetic

Correlative studies

nucleic acid sequencinggenetic

Correlative studies

mutation analysisgenetic

Correlative studies

immunohistochemistry staining methodother

Correlative studies

microarray analysisgenetic

Correlative studies

RNA analysisgenetic

Correlative studies