CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 250 enrolled
Drug / intervention
zidovudine-lamivudine-nevirapine +1 moredrug
Likely dose
zidovudine-lamivudine-nevirapine 300 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01340950
NCT01340950Phase 4Completed
CompareCT.gov

Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in China

University of California, San Diego·interventional·Posted Apr 25, 2011·Updated Apr 4, 2016

In Brief

A Phase 4 clinical trial evaluating zidovudine-lamivudine-nevirapine and tenofovir-lamivudine-efavirenz for HIV Infections and 2 related conditions. Completed, enrolled 250 participants across 2 sites.

Detailed Summary

This primary aim of the project is to determine the association between antiretroviral therapy that better distributes into the central nervous system and prevention of HIV-associated neurocognitive impairment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHIV Infections, Central Nervous System Diseases, Dementia
CountriesChina
CollaboratorsNational Institute of Mental Health (NIMH), National Center for AIDS/STD Control and Prevention, China CDC, Beijing YouAn Hospital, Beijing Ditan Hospital, Peking University

Timeline

Phase 4CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedApr 25, 2011
Enrollment StartJul 1, 2010
Primary CompletionJul 1, 2014
Study CompletionJul 1, 2015
TodayJul 2, 2026
Enrollment to primary: 4 yearsPosted 15.2 years ago

Interventions

zidovudine-lamivudine-nevirapinedrug

96 weeks of zidovudine 300 mg orally twice daily, lamivudine 300 mg orally daily, nevirapine 200 mg orally daily for the first 14 days then 200 mg orally twice daily

tenofovir-lamivudine-efavirenzdrug

96 weeks of tenofovir disoproxil fumarate 300 mg orally daily, lamivudine 300 mg orally daily, efavirenz 600 mg orally daily