At a glance
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A Two Step Approach to Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Hematologic Malignancies Using One Human Leukocyte Antigen Partially-Matched Related Donor
In Brief
A Phase 2 clinical trial evaluating Total Body Irradiation, Donor Lymphocyte Infusion (DLI), and 5 other interventions for Hematologic Malignancy. Completed, enrolled 25 participants across 1 site.
Detailed Summary
The purpose of this research study is to examine the survival of patients undergoing partially matched hematopoietic stem cell transplant (HSCT) on a new type of treatment approach, which has been developed specifically for patients who have evidence of their disease at the time of transplant. In this research study, a way of strengthening the response of the donor cells against the disease has been developed. Patients will undergo one additional day between the two steps of the transplant which may allow their donor's cells to fight the disease more effectively.
Study Details
Timeline
Interventions
Undergo TBI
Undergo DLI
Given IV
Given IV or PO
Given IV or PO
Undergo allogeneic HSCT
Correlative studies