CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 192 enrolled
Drug / intervention
DCS (D-Cycloserine ) + Prolonged Imaginal Exposure +3 moredrug
Likely dose
DCS (D-Cycloserine ) + Prolonged Imaginal Exposure 50mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01352637
NCT01352637Phase 3Completed
CompareCT.gov

Enhancing Exposure Therapy for PTSD: Virtual Reality and Imaginal Exposure With a Cognitive Enhancer

Weill Medical College of Cornell University·interventional·Posted May 12, 2011·Updated Jul 2, 2019

In Brief

A Phase 3 clinical trial evaluating DCS (D-Cycloserine ) + Prolonged Imaginal Exposure, DCS (D-Cycloserine ) + Virtual Reality Exposure, and 2 other interventions for Post Traumatic Stress Disorder. Completed, enrolled 192 participants across 5 sites.

Detailed Summary

The purpose of this study is to test the differences between four active treatment conditions for combat-related Post Traumatic Stress Disorder (PTSD): virtual reality exposure therapy (VRE) or prolonged imaginal exposure therapy (PE), both with DCS or placebo, as well as to examine predictors for PTSD and response to treatment in active duty military personnel, veterans, and civilians who served in Iraq and Afghanistan.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPost Traumatic Stress Disorder
CountriesUnited States
CollaboratorsUnited States Department of Defense, Emory University, University of Southern California, VA Long Beach Healthcare System, National Intrepid Center of Excellence

Timeline

Phase 3CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedMay 12, 2011
Enrollment StartMay 1, 2011
Primary CompletionSep 1, 2018
TodayJul 2, 2026
Enrollment to primary: 7.3 yearsPosted 15.1 years ago

Interventions

DCS (D-Cycloserine ) + Prolonged Imaginal Exposuredrug

50mg DCS (taken once a week on the day of the therapy session) + Prolonged Imaginal Exposure

DCS (D-Cycloserine ) + Virtual Reality Exposuredrug

50mg DCS (taken once a week on the day of the therapy session) + Virtual Reality Exposure

Placebo + Prolonged Imaginal Exposuredrug

Placebo (taken once a week on the day of the therapy session) + Prolonged Imaginal Exposure

Placebo (sugar pill) + Virtual Reality Exposuredrug

Placebo (taken once a week on the day of the therapy session) + Virtual Reality Exposure