At a glance
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The Role of Vitamin D in Chronic Urticaria and Angioedema Treatment
In Brief
A clinical study evaluating High Dose Vitamin D3 and Low Dose Vitamin D3 for Urticaria and 3 related conditions. Completed, enrolled 42 participants across 1 site.
Detailed Summary
This clinical study was designed based on our hypothesis that vitamin D plays an important role in chronic urticaria and that high dose supplementation with vitamin D in subjects with chronic urticaria will improve clinical response. This clinical study will investigate our hypothesis in three Specific Aims: 1. Determine whether high dosing vitamin D supplementation (4000 IU/day) reduces medication usage (primary outcome) and urticaria severity score (secondary outcome) in subjects with chronic urticaria as compared to low dosing (600 IU/day). 2. Determine if high dosing of vitamin D (4000 IU/day) is safe and well-tolerated in subjects with chronic urticaria with or without baseline vitamin D deficiency. 3. Investigate whether there is an association with serum 25-hydroxyvitamin D levels, vitamin D receptor mRNA expression, and chronic urticaria severity.
Study Details
Timeline
Interventions
Vitamin D 4000 IU per day for 3 months
Vitamin D 600 IU per day