CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 6 enrolled
Drug / intervention
14C-labeled Pyronaridinedrug
Likely dose
14C-labeled Pyronaridine 720 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01383109
NCT01383109Phase 1Completed

A Human Mass Balance Study of Pyronaridine Using Accelerator Mass Spectrometry

Medicines for Malaria Venture·interventional·Posted Jun 28, 2011·Updated Jan 26, 2022

In Brief

A Phase 1 clinical trial evaluating 14C-labeled Pyronaridine for Malaria. Completed, enrolled 6 participants across 1 site.

Detailed Summary

The combination of pyronaridine and artesunate is an antimalarial therapy in development. This mass balance study is intended to determine the rate and extent of excretion of total radioactivity in urine and feces following administration of a single oral micro-dose of 14C-pyronaridine in humans.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMalaria
CountriesSwitzerland

Timeline

Phase 1CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedJun 28, 2011
Enrollment StartJun 1, 2011
Primary CompletionSep 1, 2011
Study CompletionDec 1, 2011
TodayJul 2, 2026
Enrollment to primary: 3 monthsPosted 15.0 years ago

Interventions

14C-labeled Pyronaridinedrug

Single dose of 720 mg Pyronaridine together with 14C-Pyronaridine (approx. 100 µg, 800 nCi).