At a glance
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Neural Cardiac Therapy for Heart Failure Study
In Brief
A clinical study evaluating Implant of investigational device system, Titration during the randomization phase, and 2 other interventions for Heart Failure and Congestive Heart Failure. Active but no longer recruiting, targeting 118 participants across 21 sites in 8 countries.
Detailed Summary
The NECTAR-HF feasibility trial is designed to evaluate the application of right vagal nerve stimulation in heart failure patients with a New York Heart Association Class III, an ejection fraction equal to or less than 35 %, and a narrow QRS duration equal to or less than 130 ms.
Study Details
Timeline
Interventions
Vagus nerve stimulation lead was wrapped around the right cervical vagus nerve and then connected to a stimulator permanently implanted in the right pectoral region.
Amplitude of the chronically delivered vagus nerve stimulation in the experimental arm was adjusted to the highest tolerable by patient value. No chronically delivered vagus nerve stimulation in the control arm during the randomization phase.
Amplitude of the chronically delivered vagus nerve stimulation was adjusted to the highest tolerable by patient value in all patients in both arms of the study.
Blood draw before implant and 6 months after implant at the end of the randomization phase.