CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 19 enrolled
Drug / intervention
Coenzyme Q10drug
Likely dose
Coenzyme Q10 400 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01390389
NCT01390389N/ACompleted
CompareCT.gov

Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression: A 31 Phosphorus MR Spectroscopy Study

Mclean Hospital·interventional·Posted Jul 11, 2011·Updated Dec 7, 2017

In Brief

A clinical study evaluating Coenzyme Q10 for Bipolar Depression. Completed, enrolled 19 participants across 1 site.

Detailed Summary

The investigators propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults. The investigators would also like to investigate changes in brain energy metabolites associated with CoQ10 administration in older bipolar individuals. Finally, resting state functional Magnetic Resonance Imaging (fMRI) will be conducted in order to explore frontal and limbic circuitry in geriatric bipolar disorder. * Primary Hypothesis: Baseline beta NTP and NAA will be lower, and PCr and lactate higher in Geri BPD compared with older healthy controls * Secondary Hypothesis: Changes in PCr and beta NTP will be demonstrated in Geri BD group challenged with CoQ 10.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBipolar Depression
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

N/ACompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedJul 11, 2011
Enrollment StartJul 1, 2011
Primary CompletionJul 1, 2012
TodayJul 2, 2026
Enrollment to primary: 1 yearPosted 15.0 years ago

Interventions

Coenzyme Q10drug

Single pill consists of 400 mg and is delivered PO. CoQ10 dosing guidelines: * Visit 1 (baseline) start at 400mg once a day for two weeks * Visit 2 (within 7 days of baseline visit) increase to 800 mg once a day for two weeks The dosage of CoQ10 can be titrated in a more gradual manner depending on clinical response and tolerability of the medication, but cannot be titrated any more rapidly than the schedule above.