CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 27 enrolled
Drug / intervention
menadione topical lotion +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01393821
NCT01393821N/ACompleted
CompareCT.gov

A Randomized, Double-Blind Placebo-Controlled Exploration of a Topical Menadione-Containing Lotion to the Face for Prevention and Palliation of Epidermal Growth Factor Receptor Inhibitor-Induced Cutaneous Discomfort and Psychological Distress

Mayo Clinic·interventional·Posted Jul 13, 2011·Updated May 16, 2025

In Brief

A clinical study evaluating menadione topical lotion, placebo, and 2 other interventions for Dermatologic Complications and 2 related conditions. Completed, enrolled 27 participants across 2 sites.

Detailed Summary

This clinical trial studies menadione topical lotion in treating skin discomfort and psychological distress in patients with cancer receiving panitumumab, erlotinib hydrochloride, or cetuximab. Menadione topical lotion may prevent rash or other skin discomfort and help alleviate psychological distress and pain in patients receiving treatment with panitumumab, erlotinib hydrochloride, or cetuximab

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDermatologic Complications, Malignant Neoplasm, Pain
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

N/ACompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedJul 13, 2011
Enrollment StartJan 23, 2012
Primary CompletionMay 11, 2013
Study CompletionJul 14, 2018
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 15.0 years ago

Interventions

menadione topical lotiondrug

Given topically

placeboother

Given topically

questionnaire administrationother

Ancillary studies

management of therapy complicationsprocedure

Given menadione topical lotion