At a glance
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Long Term Antihypertensive Exposure and Adverse Metabolic Effects: PEAR Follow-Up Study
In Brief
A Phase 4 clinical trial evaluating Oral Glucose Tolerance Test for Drug Induced Hyperglycemia and Secondary Hyperlipidemia. Completed, enrolled 44 participants across 1 site.
Detailed Summary
This is a research study of the long term effects on blood sugar and cholesterol of blood pressure lowering medications. People are invited to participate in this research study if they participated in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR 1, NCT00246519 or PEAR 2, NCT01203852) study and are still taking a thiazide diuretic. In PEAR, the effects on blood pressure, blood sugar, and cholesterol of the high blood pressure drugs hydrochlorothiazide and atenolol over an 18 week period were evaluated. This PEAR follow-up study will determine the effects of thiazide diuretics on blood sugar and cholesterol, but in the period since the PEAR trial. The study hypothesis is that long term exposure to thiazide diuretics results in larger increases in blood sugar and cholesterol levels than short term exposure.
Study Details
Timeline
Interventions
Administration of 75 gram oral glucose load and three plasma glucose measurements (including baseline).