CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 44 enrolled
Drug / intervention
Sitagliptin (DPP4 inhibitor) +5 moredrug
Likely dose
Sitagliptin (DPP4 inhibitor) 200 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01413542
NCT01413542N/ACompleted
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Pharmacogenetics of Ace Inhibitor-Associated Angioedema:Aim 1

Vanderbilt University·interventional·Posted Aug 10, 2011·Updated Nov 4, 2015

In Brief

A clinical study evaluating Sitagliptin (DPP4 inhibitor), Substance P,, and 4 other interventions for Hypertension and Diabetes Type 2. Completed, enrolled 44 participants across 1 site.

Detailed Summary

The investigators would like to find out if sitagliptin (dipeptidyl peptidase-4 or DPP4 inhibition), a drug to treat diabetes, affects blood vessel relaxation in healthy people receiving enalapril (angiotensin converting enzyme or ACE inhibition), a blood pressure medicine. Understanding how these drugs interact in healthy people will help us learn their potential effects in people who have diabetes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension, Diabetes Type 2
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedAug 10, 2011
Enrollment StartNov 1, 2011
Primary CompletionJul 1, 2013
Study CompletionJul 1, 2014
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 14.9 years ago

Interventions

Sitagliptin (DPP4 inhibitor)drug

Sitagliptin 200 mg (DPP4 inhibitor) or matching placebo will be given one hour prior to intra-arterial infusions

Substance P,drug

Substance P intra-brachial artery (2,4,8 pmol/min)

bradykinindrug

bradykinin intra-brachial artery (23.6, 47.2, and 94.3 pmol/min)

enalaprilat (ACE inhibitor)drug

intra-brachial artery(0.33 µg/min per 100 mL forearm volume)

Glucagon-like peptide 1drug

intra-brachial artery (0.45-3.60 pmol/min)

brain natriuretic peptidedrug

Intra-brachial artery (0.90, 1.80 and 3.6 pmol/min)