At a glance
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A Phase III Trial of Adjuvant Chemotherapy Following Chemoradiation as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone: The OUTBACK Trial
In Brief
A Phase 3 clinical trial evaluating Brachytherapy, Carboplatin, and 4 other interventions for Cervical Adenocarcinoma and 7 related conditions. Completed, enrolled 926 participants across 326 sites in 5 countries.
Detailed Summary
This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with cervical cancer has spread from where it started to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as cisplatin, carboplatin, and paclitaxel, work in different ways to stop the growth of \[cancer/tumor\] cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. External radiation therapy uses high-energy x rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. It is not yet known whether giving cisplatin and external and internal radiation therapy together with carboplatin and paclitaxel kills more tumor cells.
Study Details
Timeline
Interventions
Undergo brachytherapy
Given IV
Given IV
Undergo external beam radiation therapy
Given IV
Ancillary studies