At a glance
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Combined Wake Therapy, Light Therapy, and Lithium for Bipolar and Refractory Depression
In Brief
A clinical study evaluating Wake Therapy, light box, and 1 other intervention for Major Depressive Disorder and Bipolar Disorder. Completed, enrolled 8 participants across 2 sites.
Detailed Summary
This pilot study seeks to replicate previous findings that sleep deprivation results in marked improvement in depression symptoms, as well as to test whether concurrent treatment with Light Therapy and Lithium are successful in locking in and maintaining therapeutic effects in both bipolar and unipolar depressed subjects.
Study Details
Timeline
Interventions
Maintaining wakefulness on alternating nights over 7 days, with continued sleep deprivation the next day.
use of a lightbox titrated between 15-60 minutes (typically 30 minutes), timed according to chronotype score on the Morningness-Eveningness Questionnaire
For patients not already taking lithium, dose will start at 600 mg daily (all in the evening) and be adjusted in 300 mg/d increments according to weekly blood levels (i.e., lithium dose may be changed once a week if most recent blood level is too low; if too high, it will be decreased or temporarily discontinued as clinically indicated; 150 mg increments will be utilized if multiples of 300 mg result in intolerance or blood levels outside the target range (0.6 - 1.0 mEq/L)