At a glance
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Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial
In Brief
A Phase 2 clinical trial evaluating Dextromethorphan for Central Neuropathic Pain and 2 related conditions. Completed, enrolled 26 participants across 1 site.
Detailed Summary
This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of three doses of chronic oral (PO) dextromethorphan compared to placebo in central neuropathic pain following spinal cord injury. Subjects' maximally tolerated doses (MTD) were first determined to establish individual dose-analgesic response relationships in a run-in period; following a washout period, subjects were then randomized to receive an order of four doses of dextromethorphan (including placebo) in a 4x4 Latin square cross-over design.
Study Details
Timeline
Interventions
0, 25, 50 and 100% of maximum tolerated dose, each administered over a 4 week period