At a glance
ClinicalIndex Comparison RecordPhase 1Completed· 31 enrolled
Drug / intervention
MK-8457 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Multiple-Dose Clinical Trial to Study the Effect of MK-8457 on Ambulatory Blood Pressure in Hypertensive Patients
In Brief
A Phase 1 clinical trial evaluating MK-8457 and Placebo for MK-8457 for Hypertension. Completed, enrolled 31 participants across 2 sites.
Detailed Summary
This study will evaluate the effect of treatment with multiple doses of MK-8457 on systolic blood pressure in participants with mild to moderate hypertension in addition to safety and tolerability. The study hypothesis is that MK-8457 does not increase systolic blood pressure to a clinically significant extent, as measured by 24-hour mean ambulatory systolic blood pressure change from baseline after 10 days of dosing.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension
CountriesUnited States
Collaborators--
Timeline
Phase 1CompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedOct 2011
Enrollment StartOct 2011
Primary CompletionFeb 2012
Study CompletionMar 2012
TodayJul 2026
First PostedOct 4, 2011
Enrollment StartOct 25, 2011
Primary CompletionFeb 18, 2012
Study CompletionMar 3, 2012
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 14.7 years ago
Interventions
MK-8457drug
10 x 10-mg capsule BID for 10 days
Placebo for MK-8457drug
10 x 10-mg capsule BID for 10 days