At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of Antiangiogenic Therapy With Pazopanib Prior to Preoperative Chemotherapy for Subjects With Extremity Soft Tissue Sarcomas: A Randomized Study to Evaluate Response by Imaging
In Brief
A clinical study evaluating Doxorubicin Hydrochloride, External Beam Radiation Therapy, and 6 other interventions for Stage IIA Adult Soft Tissue Sarcoma and 2 related conditions. Completed, enrolled 23 participants across 1 site.
Detailed Summary
This randomized pilot clinical trial studies pazopanib hydrochloride followed by chemotherapy and surgery in treating patients with soft tissue sarcoma. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes that are needed for cell growth and may also stop the growth of soft tissue sarcoma by blocking blood flow to the tumor. Giving pazopanib hydrochloride and chemotherapy before surgery may make the tumor smaller and reduce the amount of tissue that needs to be removed.
Study Details
Timeline
Interventions
Given IV
Undergo external beam radiation therapy
Given IV
Correlative studies
Given PO
Correlative studies
Given PO
Undergo surgery