At a glance
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Controlled Adverse Environment: A Pilot Study to Evaluate Tear Film Stability and Tear Evaporation
In Brief
A clinical study evaluating temperature and humidity for Environmental Exposure. Completed, enrolled 10 participants across 1 site.
Detailed Summary
Dry eye and ocular surface disease account for a lot of morbidity and socio-economic burden in Asia and the rest of the world. This is a small pilot study to evaluate tear function under different conditions of humidity and temperature. This data will be useful for designing future trials in ocular surface and dry eye. The data will likely be used to propose a larger national funded project involving clinical trials. This study involves collaboration between engineers, ocular surface clinicians as well as specialists from the defence science organisation. When successfully completed, the project will increase the capability of Singapore Eye Research Institute and Singapore National Eye Centre to support future industry and academic research in the ocular surface.
Study Details
Timeline
Interventions
The volunteer is exposed to a controlled environment with a chamber setting of: 1. 25°C and 45% humidity; 2. 25°C and 65% humidity; 3. 30°C and 45% humidity; 4. 30°C and 65% humidity After an adaptation period of at least 20 minutes, participants underwent measurements of tear evaporation and tear film break up time. After collection of data, the chamber settings were adjusted to the next condition.