CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 17 enrolled
Drug / intervention
Naltrexone High Dose +1 moredrug
Likely dose
Naltrexone High Dose 100mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01462227
NCT01462227N/ACompleted
CompareCT.gov

The Effect of Opiate Blockade With Naltrexone on Counterregulatory Mechanisms in Hypoglycemia

Yale University·interventional·Posted Oct 31, 2011·Updated Feb 18, 2016

In Brief

A clinical study evaluating Naltrexone High Dose and Naltrexone Low Dose for Hypoglycemia. Completed, enrolled 17 participants across 1 site.

Detailed Summary

Insulin treatment often causes the blood glucose levels to fall too low. The body usually responds to low blood glucose levels by releasing hormones which act against the insulin to help correct the low blood glucose levels. However, this hormone response can be altered in people with diabetes. Currently there are no therapeutic agents that can be used to improve the recovery from hypoglycemia (low blood sugar). Naltrexone is a tablet used to help people who are addicted to alcohol or morphine-based drugs to remain drug and alcohol-free but it can also affect the levels of the hormones which are released during hypoglycemia. The aim of this study is to determine whether naltrexone can be used to improve and accelerate the recovery from hypoglycemia in patients with type 1 diabetes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypoglycemia
CountriesUnited States
CollaboratorsNational Institutes of Health (NIH)

Timeline

N/ACompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedOct 31, 2011
Enrollment StartAug 1, 2011
Primary CompletionOct 1, 2013
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 14.7 years ago

Interventions

Naltrexone High Dosedrug

Naltrexone 100mg for two administrations.

Naltrexone Low Dosedrug

Naltrexone 50mg for two administrations.