At a glance
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Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting
In Brief
A Phase 4 clinical trial evaluating Aprepitant, Ondansetron, and 2 other interventions for Postoperative Nausea and Vomiting (PONV) and Nausea. Completed, enrolled 122 participants across 1 site.
Detailed Summary
This study is being done to determine the efficacies of two preventative drug combinations for postoperative nausea and vomiting in patients undergoing neurosurgery. The aim of this study is to compare the efficacy of using aprepitant instead of ondansetron in combination with dexamethasone and promethazine for post-operative nausea and vomiting prophylaxis. By completing this comparison study investigators will determine the most efficacious drug combination which will allow us to enhance the overall comfort and satisfaction of neurosurgical patients in the immediate postoperative period.
Study Details
Timeline
Interventions
Subject will receive 40 mg of Aprepitant versus placebo PO before anesthesia induction
Subject will receive 4 mg of Ondansetron IV versus placebo around anesthesia induction
Subject will receive 25 mg of Promethazine IV around anesthesia induction
Subject will receive 10 mg of Dexamethasone IV around anesthesia induction