At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effects of Red Blood Cell Transfusion on Mortality and Morbidity in Patients With Septic Shock
In Brief
A Phase 3 clinical trial evaluating SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion for Septic Shock. Completed, enrolled 1,005 participants across 32 sites in 4 countries.
Detailed Summary
Patients with blood poisoning - sepsis - often receive blood transfusions in the intensive care unit. The evidence that blood transfusion leads to improved outcome is limited and the blood may be harmful to some of these patients. To bridge the gap between clinical practice and evidence, a large randomised clinical trial is needed to document the efficacy and safety of RBC transfusion in these very sick patients
Study Details
Timeline
Interventions
One unit prestorage, leuko-depleted SAGM blood at haemoglobin at 9.0 g/dl (5.6 mM) or less at point-of-care testing
One unit prestorage, leuko-depleted SAGM blood at haemoglobin 7.0 g/dl (4.3 mM) or less at point-of-care testing