At a glance
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Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease
In Brief
A Phase 4 clinical trial evaluating hepatitis, alcohol, probiotics and alcohol, hepatitis, Placebo for Alcoholic Liver Disease. Completed, enrolled 130 participants across 1 site.
Detailed Summary
Background/Aims: The investigators explored the therapeutic effects of probiotics in patients with AH. Methods: Between September 2010 and April 2012, the investigators conducted a 7-day, double-controlled, randomized, prospective clinical trial comparing the efficacy of probiotics in improving liver enzymes, LPS, pro-inflammatory cytokines. AH was defined as an aspartate aminotransferase (AST)/alanine aminotransferase (ALT) \> 2 and elevated AST (ALT) level with an alcohol consumption history within 48 hours. Patients were randomized to receive 7 days of probiotics (1500 mg/day) or placebo. The levels of liver enzymes, modified Discriminant Function (mDF), LPS, and pro-inflammatory cytokines were checked at baseline and again after therapy.
Study Details
Timeline
Interventions
7 days of probiotics (1500 mg/day)
Placebos of the same shape and size were manufactured at Pharmaceutical Corporation.