CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 138 enrolled
Drug / intervention
18F-Fluoromisonidazole +10 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01507428
NCT01507428Phase 2Completed
CompareCT.gov

Randomized Phase II Trial of Individualized Adaptive Radiotherapy Using During-Treatment FDG-PET/CT and Modern Technology in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

National Cancer Institute (NCI)·interventional·Posted Jan 10, 2012·Updated Apr 21, 2026

In Brief

A Phase 2 clinical trial evaluating 18F-Fluoromisonidazole, Carboplatin, and 7 other interventions for Stage III Lung Non-Small Cell Cancer AJCC v7 and 2 related conditions. Completed, enrolled 138 participants across 31 sites in 2 countries.

Detailed Summary

This randomized phase II trial studies how well positron emission tomography (PET)/computed tomography (CT)-guided radiation therapy works compared to standard radiation therapy in treating patients with stage III non-small cell lung cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Using imaging procedures, such as PET and CT scans, to guide the radiation therapy, may help doctors deliver higher doses directly to the tumor and cause less damage to healthy tissue.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStage III Lung Non-Small Cell Cancer AJCC v7, Stage IIIA Lung Non-Small Cell Cancer AJCC v7, Stage IIIB Lung Non-Small Cell Cancer AJCC v7
CountriesCanada, United States
CollaboratorsNRG Oncology

Timeline

Phase 2CompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedJan 10, 2012
Enrollment StartFeb 22, 2012
Primary CompletionAug 17, 2020
Study CompletionMay 20, 2022
TodayJul 2, 2026
Enrollment to primary: 8.5 yearsPosted 14.5 years ago

Interventions

18F-Fluoromisonidazoledrug

Undergo FMISO PET/CT (Correlative studies)

Carboplatindrug

Given IV

Computed Tomographyprocedure

Undergo FDG PET/CT

Computed Tomographyprocedure

Undergo FMISO PET/CT (Correlative studies)

External Beam Radiation Therapyradiation

Undergo radiotherapy

Fludeoxyglucose F-18drug

Undergo FDG PET/CT

Image-Guided Adaptive Radiation Therapyradiation

Undergo individualized adaptive radiotherapy

Laboratory Biomarker Analysisother

Correlative studies

Paclitaxeldrug

Given IV

Positron Emission Tomographyprocedure

Undergo FDG PET/CT

Positron Emission Tomographyprocedure

Undergo FMISO PET/CT (Correlative studies)