At a glance
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Cardiac Remote Ischemic Preconditioning Prior to Elective Major Vascular Surgery
In Brief
A Phase 2 clinical trial evaluating Preconditioning and Control for Peripheral Arterial Disease and Vascular Surgery. Completed, enrolled 201 participants across 1 site.
Detailed Summary
The investigators have previously shown that elective vascular surgery is a high-risk operation with an anticipated risk of either death or heart attack of 15%. This study is testing whether a protocol of remote ischemic preconditioning (RIPC) applied 24 hours prior to the operation is safe, feasible and reduces the incidence of an adverse, perioperative cardiac complication.
Study Details
Timeline
Interventions
Blood pressure cuff inflated to 200 mmHg in the upper extremity for 5 minutes to cause forearm ischemia by external compression of the brachial artery. This will be followed by 5 minutes of cuff deflation to allow for preperfusion. The ischemia-reperfusion cycle will be repeated 3 times for a total duration of 30 minutes, equally divided between ischemia and reperfusion.
Blood pressure cuff inflated to 40-50 mmHg in the upper extremity