At a glance
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Pioglitazone Treatment for Insulin Resistant Patients With Mood Disorders
In Brief
A Phase 4 clinical trial evaluating Pioglitazone and Sugar Pill for Major Depressive Disorder and Insulin Resistance. Completed, enrolled 37 participants across 1 site.
Detailed Summary
The purpose of this study is to see how an insulin sensitizing medication, Pioglitazone, can cause changes in mood in some depressed patients. Study participants receive assessment of their cognitive and metabolic functioning. If they meet criteria, they will be asked to take either Pioglitazone or a placebo for a 90-day trial. Participants will undergo an Oral Glucose Tolerance Test to measure fasting insulin and glucose levels, as well as routine blood testing. The investigators hope to quantify the role of Pioglitazone in patients with mood disorders and compare the values to those previously obtained in a healthy age-matched control population. The investigators also hope to examine the association between IR and cognitive performance and clinical course of depression in patients with mood disorders.
Study Details
Timeline
Interventions
30mg once daily for 12 weeks
Placebo