CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 795 enrolled
Drug / intervention
Denosumab +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01575873
NCT01575873Phase 3Completed

A Randomized, Double-blind, Active-controlled Study to Evaluate the Efficacy and Safety of Denosumab Compared With Risedronate in Glucocorticoid-treated Individuals

Amgen·interventional·Posted Apr 12, 2012·Updated Jul 27, 2018

In Brief

A Phase 3 clinical trial evaluating Denosumab, Placebo for risendronate, and 2 other interventions for Steroid-induced Osteopor, Glucocorticoid-induced Ostepor. Completed, enrolled 795 participants across 99 sites in 16 countries.

Detailed Summary

This is a 2-year study to evaluate the effect of denosumab versus risedronate in adults with glucocorticoid-induced osteoporosis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesArgentina, Belgium, Canada, Colombia, Czechia, Denmark, France, Germany, Hungary, Mexico, Netherlands, Poland, Russia, South Korea, Spain, United States
Collaborators--

Timeline

Phase 3CompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedApr 12, 2012
Enrollment StartMar 28, 2012
Primary CompletionJun 21, 2016
Study CompletionJun 29, 2017
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 14.2 years ago

Interventions

Denosumabdrug

Administered by subcutaneous injection once every 6 months

Placebo for risendronatedrug

Administered orally once a day

Risendronatedrug

Administered orally once a day

Placebo for denosumabdrug

Administered by subcutaneous injection once every 6 months