CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 48 enrolled
Drug / intervention
Running exercise +2 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01576159
NCT01576159Early Ph 1Completed
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The Effect of Mechanical Loading During Sports Exercises on Degradation of Human Articular Cartilage

Middle East Technical University·interventional·Posted Apr 12, 2012·Updated Jun 10, 2015

In Brief

A Early Phase 1 clinical trial evaluating Running exercise, Cycling exercise, and 1 other intervention for Osteoarthritis and 2 related conditions. Completed, enrolled 48 participants across 1 site.

Detailed Summary

Acute effects of physical exercise on the deformational behavior of articular cartilage and changes in cartilage oligomeric matrix protein (COMP) are definite. However, conclusive positive effects of fitness exercise on functional adaptation of articular cartilage have not been proved.Therefore, in this parallel-group randomized control trial, the investigators tested the hypothesis that adequate amount of physical exercise with enough impact would be able to stimulate the functional behavior of articular cartilage. The investigators evaluated 44 healthy males for their physical fitness levels and their blood samples were obtained before, immediately after and 0.5 h after a 30-min walking exercise. Thereafter, participants were assigned to the running, the cycling, the swimming and the control groups. At the end of 12-weeks of intervention, same measurement procedures were applied. Mixed repeated-measures ANOVA design was used for statistics. (Level of evidence: 2)

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOsteoarthritis, Articular Cartilage Disorder of Knee, Degenerative Lesion of Articular Cartilage of Knee
CountriesTurkey (Türkiye)
Collaborators--

Timeline

Early Ph 1CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedApr 12, 2012
Enrollment StartJan 1, 2008
Primary CompletionJun 1, 2008
Study CompletionSep 1, 2008
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 14.2 years ago

Interventions

Running exerciseother

During this type of exercise intervention, subjects performed weight-bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks

Cycling exerciseother

During this type of exercise intervention, subjects performed a partial weight-bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks

Swimming Exerciseother

During this type of exercise intervention, subjects performed a non-weight bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks