At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Responses to CPAP Treatment in Obese and Lean Sleep Apnea Patients
In Brief
A clinical study evaluating Positive Airway Pressure During Sleep (ResMed S9 Elite) and Usual Care for Sleep Apnea and Obesity. Completed, enrolled 450 participants across 1 site.
Detailed Summary
The investigators' overall goal is to compare the effect of CPAP treatment on intermediate cardiovascular risk measures in obese versus lean patients with obstructive sleep apnea (OSA). The overall hypothesis is that, adjusting for OSA severity and obtaining normative data from non-OSA subjects with comparable amounts of visceral adiposity, the two OSA groups will have comparable improvements in daytime sleepiness, but that the cardiovascular and metabolic improvements following CPAP therapy will be decreased in OSA patients with increased visceral adipose tissue. The investigators anticipate that, although there will be a greater absolute change in markers of sympathetic activity, inflammation and oxidative stress in obese compared to lean OSA patients following CPAP treatment, the levels will still be abnormally high in the obese patients resulting in the decreased improvements in insulin resistance, arterial blood pressure, and vascular health in obese versus lean OSA patients.
Study Details
Timeline
Interventions
Positive airway pressure during sleep (ResMed S9 Elite).
Usual care.